← Back to PAHMCJ Volume 3, Number 1 (January 2026)

Original Article

Author(s): Begum R, Akter AHMM, Ali MA, Khatun S, Rahman M, Nuruzzaman M, Das K, Rabeya T, Bari MA, Ahammad AN, Alam N

PAH Med Col J. Jan 2026; 3(1): 13-19

Abstract

Background: Acute glomerulonephritis (AGN) is a common pediatric renal disease in developing countries. Reduced serum complement C3 levels and elevated antistreptolysin O (ASO) titres are frequently observed in post-streptococcal AGN and may aid in diagnosis and assessment of disease severity.

Methods: This cross-sectional study was conducted in the Department of Pediatrics, Mymensingh Medical College Hospital, from April 2019 to March 2020, enrolling 36 children diagnosed with AGN.

Results: Most patients (63.9%) were aged 6–12 years, predominantly male, and from rural areas. Elevated ASO titres were found in 77.8% of patients, while low serum C3 levels were observed in 52.8%. Complete recovery occurred in 66.7% of cases, whereas 30.6% developed complications and 2.8% died.

Conclusion: Serum C3 levels and ASO titres are useful supportive diagnostic markers and may reflect disease severity in children with AGN, though their role in predicting short-term outcomes appears limited.

Keywords

Acute glomerulonephritis, Serum C3, Antistreptolysin O titre, Children, Post-streptococcal infection, Outcome

📄 Download Full Original Article PDF

How to cite: Begum R, Akter AHMM, Ali MA, Khatun S, Rahman M, Nuruzzaman M, Das K, Rabeya T, Bari MA, Ahammad AN, Alam N. Relation of serum C3 level and ASO titre with clinical profile and immediate outcome of Children with Acute Glomerulonephritis. PAH Med Col J. Jan 2026; 3(1): 13-19.

DOI: https://doi.org/10.70945/pahmc.v03i01.04